3LD6
Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole
Replaces: 3I3KSummary for 3LD6
Entry DOI | 10.2210/pdb3ld6/pdb |
Related | 3JUS 3JUV |
Related PRD ID | PRD_900012 |
Descriptor | Lanosterol 14-alpha demethylase, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | cytochrome p450, sterol 14alpha-demethylase, ketoconazole, structural genomics, structural genomics consortium, sgc, alternative splicing, cholesterol biosynthesis, endoplasmic reticulum, heme, iron, lipid synthesis, membrane, metal-binding, microsome, monooxygenase, nadp, oxidoreductase, polymorphism, steroid biosynthesis, sterol biosynthesis, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 110140.77 |
Authors | Strushkevich, N.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-01-12, release date: 2010-02-02, Last modification date: 2023-09-06) |
Primary citation | Strushkevich, N.,Usanov, S.A.,Park, H.W. Structural basis of human CYP51 inhibition by antifungal azoles. J.Mol.Biol., 397:1067-1078, 2010 Cited by PubMed: 20149798DOI: 10.1016/j.jmb.2010.01.075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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