3JUV
Crystal structure of human lanosterol 14alpha-demethylase (CYP51)
Summary for 3JUV
Entry DOI | 10.2210/pdb3juv/pdb |
Related | 3I3K 3JUS |
Related PRD ID | PRD_900012 |
Descriptor | Lanosterol 14-alpha demethylase, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total) |
Functional Keywords | cytochrome p450, sterol 14alpha-demethylase, structural genomics, structural genomics consortium, sgc, alternative splicing, cholesterol biosynthesis, endoplasmic reticulum, heme, iron, lipid synthesis, membrane, metal-binding, microsome, monooxygenase, nadp, oxidoreductase, polymorphism, steroid biosynthesis, sterol biosynthesis, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 54538.95 |
Authors | Strushkevich, N.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Usanov, S.A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-15, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | Strushkevich, N.,Usanov, S.A.,Park, H.W. Structural basis of human CYP51 inhibition by antifungal azoles. J. Mol. Biol., 397:1067-1078, 2010 Cited by PubMed: 20149798DOI: 10.1016/j.jmb.2010.01.075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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