3LCP

Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2

Summary for 3LCP

Entry DOI	10.2210/pdb3lcp/pdb
Descriptor	Protein ERGIC-53, Multiple coagulation factor deficiency protein 2, CALCIUM ION, ... (4 entities in total)
Functional Keywords	er-golgi transport, glycoprotein sorting, disease mutation, secretory pathway, protein transport, coagulation factor deficiency, disulfide bond, endoplasmic reticulum, golgi apparatus, lectin, membrane, polymorphism, transmembrane, transport, calcium, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein: P49257 Endoplasmic reticulum-Golgi intermediate compartment: Q8NI22
Total number of polymer chains	4
Total formula weight	75511.93
Authors	Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y. (deposition date: 2010-01-11, release date: 2010-01-26, Last modification date: 2023-09-06)
Primary citation	Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y. Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII. Febs Lett., 584:878-882, 2010 Cited by PubMed: 20138881 DOI: 10.1016/j.febslet.2010.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation