3L3R

Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants

Summary for 3L3R

• Entry DOI: 10.2210/pdb3l3r/pdb
• Related: 3F8Y
• Descriptor: Dihydrofolate reductase, 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: dihydrofolate reductase, antifolate, active site mutants, nadp, one-carbon metabolism, oxidoreductase
• Biological source: Homo sapiens
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 1
• Total formula weight: 22527.25

Authors

Cody, V. (deposition date: 2009-12-17, release date: 2011-01-05, Last modification date: 2023-09-06)

• Primary citation: Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A.; Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.; Antimicrob.Agents Chemother., 57:2669-2677, 2013; PubMed: 23545530; DOI: 10.1128/AAC.00172-13

Experimental method

X-RAY DIFFRACTION (2 Å)