3KRJ
cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide
Summary for 3KRJ
Entry DOI | 10.2210/pdb3krj/pdb |
Related | 3KRL |
Descriptor | Macrophage colony-stimulating factor 1 receptor, Basic fibroblast growth factor receptor 1, ACETATE ION, 4-cyano-N-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1H-imidazole-2-carboxamide, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, chimera, atp-binding, disulfide bond, glycoprotein, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P07333 |
Total number of polymer chains | 1 |
Total formula weight | 38498.99 |
Authors | Schubert, C. (deposition date: 2009-11-18, release date: 2010-12-01, Last modification date: 2023-09-06) |
Primary citation | Illig, C.R.,Manthey, C.L.,Wall, M.J.,Meegalla, S.K.,Chen, J.,Wilson, K.J.,Ballentine, S.K.,Desjarlais, R.L.,Schubert, C.,Crysler, C.S.,Chen, Y.,Molloy, C.J.,Chaikin, M.A.,Donatelli, R.R.,Yurkow, E.,Zhou, Z.,Player, M.R.,Tomczuk, B.E. Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141). J.Med.Chem., 54:7860-7883, 2011 Cited by PubMed: 22039836DOI: 10.1021/jm200900q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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