3KRJ
cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor, Basic fibroblast growth factor receptor 1 | polymer | 335 | 38064.5 | 1 | UniProt (P07333) UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | c-fms, FGFR-1 |
| 2 | B (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 3 | C (A) | 4-cyano-N-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1H-imidazole-2-carboxamide | non-polymer | 375.5 | 1 | Chemie (KRJ) | |||
| 4 | D (A) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A: 538 - 678 (UniProt: P07333)
A: 679 - 699 (UniProt: P11362)
A: 753 - 922 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Gly 535 | - | expression tag |
| Val 536 | - | expression tag |
| Asp 537 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 686 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38064.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 38499.0 |
