3KR3
Crystal structure of IGF-II antibody complex
Summary for 3KR3
Entry DOI | 10.2210/pdb3kr3/pdb |
Descriptor | Insulin-like growth factor II, antibody-Fab (heavy chain), antibody-Fab (light chain), ... (5 entities in total) |
Functional Keywords | antibody-target complex, carbohydrate metabolism, glucose metabolism, glycoprotein, growth factor, hormone, mitogen, osteogenesis, secreted, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01344 |
Total number of polymer chains | 3 |
Total formula weight | 57898.48 |
Authors | Peat, T.S.,Newman, J.,Adams, T.E. (deposition date: 2009-11-17, release date: 2010-06-16, Last modification date: 2011-07-13) |
Primary citation | Dransfield, D.T.,Cohen, E.H.,Chang, Q.,Sparrow, L.G.,Bentley, J.D.,Dolezal, O.,Xiao, X.,Peat, T.S.,Newman, J.,Pilling, P.A.,Phan, T.,Priebe, I.,Brierley, G.V.,Kastrapeli, N.,Kopacz, K.,Martik, D.,Wassaf, D.,Rank, D.,Conley, G.,Huang, Y.,Adams, T.E.,Cosgrove, L. A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol.Cancer Ther., 9:1809-1819, 2010 Cited by PubMed: 20515953DOI: 10.1158/1535-7163.MCT-09-1134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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