3KR3

Crystal structure of IGF-II antibody complex

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0008083	molecular_function	growth factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H 252

Chain	Residue
D	VAL35
D	ARG40
H	SER30
H	ASN31
H	SER53

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 253

Chain	Residue
L	THR179
L	HOH255
H	LEU150
H	SER186
H	LEU187
H	SER188

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO H 254

Chain	Residue
H	GLY9
H	GLY10
H	MET117
H	THR119
H	PRO156
H	GLU157
H	PRO158
H	PRO211
H	HOH256
H	HOH320

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO L 216

Chain	Residue
L	PRO81
L	ARG109
L	ASP171
L	SER172
L	HOH291
L	HOH296

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Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlalLetyC

Chain	Residue	Details
D	CYS46-CYS60

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR193-HIS199
H	TYR203-HIS209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Region: {"description":"C"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	20
Details	Region: {"description":"A"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"28873464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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