3KMG
The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide
Summary for 3KMG
Entry DOI | 10.2210/pdb3kmg/pdb |
Related | 1fm6 1fm9 1prg 2prg |
Descriptor | Peroxisome proliferator-activated receptor gamma, Steroid Receptor Coactivator-1, 4'-[(2,3-dimethyl-5-{[(1S)-1-phenylpropyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | ppar-gamma, peroxisome proliferator-activated receptor, telmisartan, diabetes, modulator, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 4 |
Total formula weight | 68881.94 |
Authors | Gampe, R. (deposition date: 2009-11-10, release date: 2010-01-12, Last modification date: 2024-03-13) |
Primary citation | Lamotte, Y.,Martres, P.,Faucher, N.,Laroze, A.,Grillot, D.,Ancellin, N.,Saintillan, Y.,Beneton, V.,Gampe, R. Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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