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3KFA

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

Summary for 3KFA
Entry DOI10.2210/pdb3kfa/pdb
Related3KF4
DescriptorTyrosine-protein kinase ABL1, 3-{(E)-2-[6-(cyclopropylamino)-9H-purin-9-yl]ethenyl}-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide (3 entities in total)
Functional Keywordsabl, cml, drug resistance, inhibitor, atp-binding, kinase, nucleotide-binding, oncogene, tyrosine-protein kinase, transferase
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, cytoskeleton: P00520
Total number of polymer chains2
Total formula weight67601.04
Authors
Zhou, T. (deposition date: 2009-10-27, release date: 2009-12-22, Last modification date: 2023-09-06)
Primary citationZhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Sawyer, T.K.,Shakespeare, W.C.,Clackson, T.,Zhu, X.,Dalgarno, D.C.
Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Chem.Biol.Drug Des., 75:18-28, 2010
Cited by
PubMed: 19895503
DOI: 10.1111/j.1747-0285.2009.00905.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.22 Å)
Structure validation

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