3K9B
Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF)
Summary for 3K9B
Entry DOI | 10.2210/pdb3k9b/pdb |
Descriptor | Liver carboxylesterase 1, cyclohexyl (S)-methylphosphonofluoridoate (3 entities in total) |
Functional Keywords | hydrolase, organophosphorus nerve agent, alternative splicing, disulfide bond, endoplasmic reticulum, glycoprotein, polymorphism, serine esterase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum lumen: P23141 |
Total number of polymer chains | 3 |
Total formula weight | 175743.34 |
Authors | Hemmert, A.C.,Redinbo, M.R. (deposition date: 2009-10-15, release date: 2010-01-19, Last modification date: 2023-09-06) |
Primary citation | Hemmert, A.C.,Otto, T.C.,Wierdl, M.,Edwards, C.C.,Fleming, C.D.,MacDonald, M.,Cashman, J.R.,Potter, P.M.,Cerasoli, D.M.,Redinbo, M.R. Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Mol.Pharmacol., 77:508-516, 2010 Cited by PubMed: 20051531DOI: 10.1124/mol.109.062356 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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