3K74
Disruption of protein dynamics by an allosteric effector antibody
Summary for 3K74
| Entry DOI | 10.2210/pdb3k74/pdb |
| Related | 1HCV 5DFR |
| Descriptor | Dihydrofolate reductase, Nanobody (3 entities in total) |
| Functional Keywords | immunoglobulin, protein-nanobody complex, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, oxidoreductase, trimethoprim resistance |
| Biological source | Escherichia coli K-12 More |
| Total number of polymer chains | 2 |
| Total formula weight | 30570.49 |
| Authors | Oyen, D.,Srinivasan, V.,Steyaert, J.,Barlow, J. (deposition date: 2009-10-12, release date: 2010-10-20, Last modification date: 2023-09-06) |
| Primary citation | Oyen, D.,Srinivasan, V.,Steyaert, J.,Barlow, J.N. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J.Mol.Biol., 407:138-148, 2011 Cited by PubMed: 21238460DOI: 10.1016/j.jmb.2011.01.017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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