3K3J
P38alpha bound to novel DFG-out compound PF-00416121
Summary for 3K3J
Entry DOI | 10.2210/pdb3k3j/pdb |
Descriptor | Mitogen-activated protein kinase 14, 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total) |
Functional Keywords | p38alpha kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42212.96 |
Authors | Kazmirski, S.L.,DiNitto, J.P. (deposition date: 2009-10-02, release date: 2009-11-10, Last modification date: 2024-02-21) |
Primary citation | Tecle, H.,Feru, F.,Liu, H.,Kuhn, C.,Rennie, G.,Morris, M.,Shao, J.,Cheng, A.C.,Gikunju, D.,Miret, J.,Coli, R.,Xi, S.H.,Clugston, S.L.,Low, S.,Kazmirski, S.,Ding, Y.H.,Cao, Q.,Johnson, T.L.,Deshmukh, G.D.,Dinitto, J.P.,Wu, J.C.,English, J.M. The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay. Chem.Biol.Drug Des., 74:547-559, 2009 Cited by PubMed: 19843080DOI: 10.1111/j.1747-0285.2009.00884.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.995 Å) |
Structure validation
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