3K3J
P38alpha bound to novel DFG-out compound PF-00416121
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 362 | 41487.3 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (A) | 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide | non-polymer | 468.4 | 1 | Chemie (F4C) | |||
| 3 | C (A) | 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine | non-polymer | 257.2 | 1 | Chemie (I46) | |||
| 4 | D (A) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41487.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 725.6 | |
| All* | Total formula weight | 42213.0 |
