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3JZP

Human MDMX liganded with a 12mer peptide inhibitor (pDI6W)

Summary for 3JZP
Entry DOI10.2210/pdb3jzp/pdb
Related3JZO 3JZQ 3JZR 3JZS
DescriptorProtein Mdm4, pDI6W peptide (12mer), POTASSIUM ION, ... (4 entities in total)
Functional Keywordscell cycle, p53-binding protein mdm4, double minute 4 protein, alternative splicing, metal-binding, nucleus, polymorphism, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O15151
Total number of polymer chains2
Total formula weight11719.67
Authors
Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citationPhan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J.
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285:2174-2183, 2010
Cited by
PubMed: 19910468
DOI: 10.1074/jbc.M109.073056
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.74 Å)
Structure validation

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