3JVY

HIV-1 Protease Mutant G86A with DARUNAVIR

Summary for 3JVY

Entry DOI	10.2210/pdb3jvy/pdb
Related	2IEN 3JVW 3JW2
Descriptor	Gag-Pol polyprotein, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hiv-1 protease, mutant g86a, inhibitor, darunavir, aids, aspartyl protease, hydrolase, metal-binding
Biological source	Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22150.96
Authors	Tie, Y.,Weber, I.T. (deposition date: 2009-09-17, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Ishima, R.,Gong, Q.,Tie, Y.,Weber, I.T.,Louis, J.M. Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease Proteins, 78:1015-1025, 2009 Cited by PubMed: 19899162 DOI: 10.1002/prot.22625 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation