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3JUT

Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid

Summary for 3JUT
Entry DOI10.2210/pdb3jut/pdb
Related3K1X
DescriptorHeparin-binding growth factor 1, 2,5-dihydroxybenzoic acid (3 entities in total)
Functional Keywordsgrowth factor, fgf-1 inhibitors, angiogenesis, developmental protein, differentiation, heparin-binding, mitogen, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P05230
Total number of polymer chains6
Total formula weight88824.46
Authors
Fernandez, I.S.,Gimenez-Gallego, G.,Romero, A. (deposition date: 2009-09-15, release date: 2010-02-02, Last modification date: 2023-11-01)
Primary citationFernandez, I.S.,Cuevas, P.,Angulo, J.,Lopez-Navajas, P.,Canales-Mayordomo, A.,Gonzalez-Corrochano, R.,Lozano, R.M.,Valverde, S.,Jimenez-Barbero, J.,Romero, A.,Gimenez-Gallego, G.
Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285:11714-11729, 2010
Cited by
PubMed: 20145243
DOI: 10.1074/jbc.M109.064618
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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