3IPU
X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha
Summary for 3IPU
Entry DOI | 10.2210/pdb3ipu/pdb |
Related | 3IPQ 3IPS |
Descriptor | Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 4-{[methyl(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)carbamoyl]amino}benzoic acid, ... (5 entities in total) |
Functional Keywords | nuclear receptor, lxr homodimer, lxr signaling, alternative splicing, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, chromosomal rearrangement, isopeptide bond, phosphoprotein, proto-oncogene, transferase, ubl conjugation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): Q13133 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 72496.13 |
Authors | Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wijnands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennet, D.J.,McGuire, R.,Uitdehaag, J.C.M. (deposition date: 2009-08-18, release date: 2010-06-02, Last modification date: 2024-04-03) |
Primary citation | Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wynands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennett, D.J.,McGuire, R.,Uitdehaag, J.C. X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. J.Mol.Biol., 399:120-132, 2010 Cited by PubMed: 20382159DOI: 10.1016/j.jmb.2010.04.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report