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3IPU

X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006629biological_processlipid metabolic process
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0006629biological_processlipid metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE O40 A 801
ChainResidue
AHOH69
AHIS421
ALEU428
ALEU435
AHOH74
AASN225
AARG232
APHE257
ALEU260
AALA261
AARG305
APHE315

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE O40 B 801
ChainResidue
BASN225
BARG232
BPHE257
BLEU260
BMET298
BTHR302
BARG305
BPHE315
BLEU331
BPHE335
BHIS421
BLEU428
BLEU435

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 802
ChainResidue
BHOH14
BHOH14
BARG283
BARG283
DHIS690
DHIS690
DGLN694
DGLN694

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 C 802
ChainResidue
AARG283
AARG283
CHOH23
CHOH23
CHIS690
CHIS690
CGLN694
CGLN694

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER697
DSER697

226707

PDB entries from 2024-10-30

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