3IKA

Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002

Summary for 3IKA

Entry DOI	10.2210/pdb3ika/pdb
Related	2jit 2jiu 2jiv
Descriptor	Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide (3 entities in total)
Functional Keywords	egfr, t790m, wz4002, wz-4002, alternative splicing, atp-binding, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tumor suppressor, tyrosine-protein kinase, ubl conjugation
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	2
Total formula weight	75820.06
Authors	Yun, C.-H.,Eck, M.J. (deposition date: 2009-08-05, release date: 2010-01-12, Last modification date: 2021-10-13)
Primary citation	Zhou, W.,Ercan, D.,Chen, L.,Yun, C.H.,Li, D.,Capelletti, M.,Cortot, A.B.,Chirieac, L.,Iacob, R.E.,Padera, R.,Engen, J.R.,Wong, K.K.,Eck, M.J.,Gray, N.S.,Janne, P.A. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature, 462:1070-1074, 2009 Cited by PubMed: 20033049 DOI: 10.1038/nature08622 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation