3IKA
Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epidermal growth factor receptor | polymer | 331 | 37662.5 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | A | N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | non-polymer | 495.0 | 1 | Chemie (0UN) | |||
| 3 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, B: 694 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75325.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 495.0 | |
| All* | Total formula weight | 75820.1 |
