3II4

Structure of mycobacterial lipoamide dehydrogenase bound to a triazaspirodimethoxybenzoyl inhibitor

Summary for 3II4

• Entry DOI: 10.2210/pdb3ii4/pdb
• Related: 2A8X
• Descriptor: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N-[2-(2,4-dichlorophenyl)ethyl]-2-{8-[(2,4-dimethoxyphenyl)carbonyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl}acetamide, ... (4 entities in total)
• Functional Keywords: dihydrolipoyl dehydrogenase, dhldh, e3, protein-n6-(dihydrolipoyl)lysine, nad+ oxidoreductase, nad+, nadh, cytoplasm, disulfide bond, fad, flavoprotein, glycolysis, nad, oxidoreductase, redox-active center
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 101696.25

Authors

Lima, C.D. (deposition date: 2009-07-31, release date: 2010-01-26, Last modification date: 2023-09-06)

• Primary citation: Bryk, R.,Arango, N.,Venugopal, A.,Warren, J.D.,Park, Y.H.,Patel, M.S.,Lima, C.D.,Nathan, C.; Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .; Biochemistry, 49:1616-1627, 2010; PubMed: 20078138; DOI: 10.1021/bi9016186

Experimental method

X-RAY DIFFRACTION (2.42 Å)