3IGU
Crystal structure of human alpha-N-acetylgalactosaminidase, covalent intermediate
Summary for 3IGU
Entry DOI | 10.2210/pdb3igu/pdb |
Related | 3H53 3H54 3H55 |
Descriptor | Alpha-N-acetylgalactosaminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, schindler disease, kanzaki disease, disease mutation, disulfide bond, epilepsy, hydrolase, lysosome, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P17050 |
Total number of polymer chains | 2 |
Total formula weight | 96206.42 |
Authors | Clark, N.E.,Garman, S.C. (deposition date: 2009-07-28, release date: 2009-10-20, Last modification date: 2023-09-06) |
Primary citation | Clark, N.E.,Garman, S.C. The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases J.Mol.Biol., 393:435-447, 2009 Cited by PubMed: 19683538DOI: 10.1016/j.jmb.2009.08.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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