3IA6
X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist
Summary for 3IA6
Entry DOI | 10.2210/pdb3ia6/pdb |
Related | 2Q8S |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-3-{4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl}-2-(2H-1,2,3-triazol-2-yl)propanoic acid (3 entities in total) |
Functional Keywords | protein-ligand complex, dual specificity, inhibitor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 62826.99 |
Authors | Ohren, J.F. (deposition date: 2009-07-13, release date: 2009-10-13, Last modification date: 2023-09-06) |
Primary citation | Casimiro-Garcia, A.,Bigge, C.F.,Davis, J.A.,Padalino, T.,Pulaski, J.,Ohren, J.F.,McConnell, P.,Kane, C.D.,Royer, L.J.,Stevens, K.A.,Auerbach, B.,Collard, W.,McGregor, C.,Song, K. Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists. Bioorg.Med.Chem., 17:7113-7125, 2009 Cited by PubMed: 19783444DOI: 10.1016/j.bmc.2009.09.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
Download full validation report