3IA4
Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
Summary for 3IA4
| Entry DOI | 10.2210/pdb3ia4/pdb |
| Related | 3IA5 |
| Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total) |
| Functional Keywords | dhfr dihydrofolate reductase, nadph, methotrexate, oxidoreductase |
| Biological source | Moritella profunda |
| Total number of polymer chains | 4 |
| Total formula weight | 78034.52 |
| Authors | Levy, C. (deposition date: 2009-07-13, release date: 2009-07-21, Last modification date: 2024-02-21) |
| Primary citation | Hay, S.,Evans, R.M.,Levy, C.,Loveridge, E.J.,Wang, X.,Leys, D.,Allemann, R.K.,Scrutton, N.S. Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted? Chembiochem, 10:2348-2353, 2009 Cited by PubMed: 19681091DOI: 10.1002/cbic.200900367 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report
