3IA4
Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydrofolate reductase | polymer | 162 | 18308.8 | 4 | UniProt (Q70YQ6) Pfam (PF00186) | Moritella profunda | |
| 2 | E, G, I, K (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | F, H, J, L (A, B, C, D) | METHOTREXATE | non-polymer | 454.4 | 4 | Chemie (MTX) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 963 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 73235.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4799.4 | |
| All* | Total formula weight | 78034.5 |
