3I6M
3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine
Summary for 3I6M
Entry DOI | 10.2210/pdb3i6m/pdb |
Related | 1DX6 1QTI 1W4L 1W6R 1W76 3I6Z |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | serine hydrolase, cholinesterase, neurotransmitter degradation, alzheimer's disease, bis-functional galanthamine derivative, alternative splicing, cell junction, cell membrane, disulfide bond, glycoprotein, gpi-anchor, hydrolase, lipoprotein, membrane, serine esterase, synapse |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 61491.36 |
Authors | Lamba, D.,Bartolucci, C. (deposition date: 2009-07-07, release date: 2010-01-12, Last modification date: 2023-09-06) |
Primary citation | Bartolucci, C.,Haller, L.A.,Jordis, U.,Fels, G.,Lamba, D. Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53:745-751, 2010 Cited by PubMed: 20025280DOI: 10.1021/jm901296p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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