3I5S

Crystal structure of PI3K SH3

Summary for 3I5S

Entry DOI	10.2210/pdb3i5s/pdb
Related	3I5R
Descriptor	Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION (2 entities in total)
Functional Keywords	sh3 domain, alternative splicing, disease mutation, host-virus interaction, phosphoprotein, polymorphism, sh2 domain, ubl conjugation, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	37841.48
Authors	Batra-Safferling, R.,Granzin, J.,Modder, S.,Hoffmann, S.,Willbold, D. (deposition date: 2009-07-06, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	Batra-Safferling, R.,Granzin, J.,Modder, S.,Hoffmann, S.,Willbold, D. Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding. Biol.Chem., 391:33-42, 2010 Cited by PubMed: 19919182 DOI: 10.1515/BC.2010.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation