3I3S
Crystal Structure of H-Ras with Thr50 replaced by Isoleucine
Summary for 3I3S
Entry DOI | 10.2210/pdb3i3s/pdb |
Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | gtpases, h-ras, noonan syndrome, cell membrane, disease mutation, golgi apparatus, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, palmitate, prenylation, proto-oncogene, s-nitrosylation, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01112 |
Total number of polymer chains | 1 |
Total formula weight | 19522.44 |
Authors | Gremer, L.,Dvorsky, R.,Merbitz-Zahradnik, T.,Wittinghofer, A.,Ahmadian, M.R. (deposition date: 2009-06-30, release date: 2009-12-22, Last modification date: 2023-09-06) |
Primary citation | Cirstea, I.C.,Kutsche, K.,Dvorsky, R.,Gremer, L.,Carta, C.,Horn, D.,Roberts, A.E.,Lepri, F.,Merbitz-Zahradnik, T.,Konig, R.,Kratz, C.P.,Pantaleoni, F.,Dentici, M.L.,Joshi, V.A.,Kucherlapati, R.S.,Mazzanti, L.,Mundlos, S.,Patton, M.A.,Silengo, M.C.,Rossi, C.,Zampino, G.,Digilio, C.,Stuppia, L.,Seemanova, E.,Pennacchio, L.A.,Gelb, B.D.,Dallapiccola, B.,Wittinghofer, A.,Ahmadian, M.R.,Tartaglia, M.,Zenker, M. A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat.Genet., 42:27-29, 2010 Cited by PubMed: 19966803DOI: 10.1038/ng.497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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