3HGZ
Crystal structure of human insulin-degrading enzyme in complex with amylin
Summary for 3HGZ
Entry DOI | 10.2210/pdb3hgz/pdb |
Descriptor | Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION, ... (4 entities in total) |
Functional Keywords | insulin degrading enzyme, ide, amylin, cystein free, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, amidation, amyloid, cleavage on pair of basic residues, disulfide bond, hormone, secreted |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14735 Secreted: P10997 |
Total number of polymer chains | 4 |
Total formula weight | 232288.88 |
Authors | Guo, Q.,Bian, Y.,Tang, W.J. (deposition date: 2009-05-14, release date: 2009-12-08, Last modification date: 2021-10-13) |
Primary citation | Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J. Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395:430-443, 2010 Cited by PubMed: 19896952DOI: 10.1016/j.jmb.2009.10.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
Download full validation report