3HGZ
Crystal structure of human insulin-degrading enzyme in complex with amylin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, B) | Insulin-degrading enzyme | polymer | 969 | 112169.7 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) | Homo sapiens (human) | Insulin protease, Insulinase, Insulysin |
2 | C, D (D, E) | Islet amyloid polypeptide | polymer | 37 | 3909.3 | 2 | UniProt (P10997) Pfam (PF00214) | Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide | |
3 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence modifications
A, B: 43 - 1011 (UniProt: P14735)
PDB | External Database | Details |
---|---|---|
Leu 110 | Cys 110 | engineered mutation |
Gln 111 | Glu 111 | engineered mutation |
Ser 171 | Cys 171 | engineered mutation |
Ala 178 | Cys 178 | engineered mutation |
Val 257 | Cys 257 | engineered mutation |
Leu 414 | Cys 414 | engineered mutation |
Asn 573 | Cys 573 | engineered mutation |
Ser 590 | Cys 590 | engineered mutation |
Ser 789 | Cys 789 | engineered mutation |
Ala 812 | Cys 812 | engineered mutation |
Ala 819 | Cys 819 | engineered mutation |
Ser 904 | Cys 904 | engineered mutation |
Asn 966 | Cys 966 | engineered mutation |
Ala 974 | Cys 974 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 232158.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 232288.9 |