3HA8

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/Compound 14b

Summary for 3HA8

• Entry DOI: 10.2210/pdb3ha8/pdb
• Related: 3HA6
• Descriptor: Mitogen-activated protein kinase 14, N~2~-{4-[6-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)-1H-benzimidazol-1-yl]-6-ethoxy-1,3,5-triazin-2-yl}-3-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N-methyl-L-alaninamide (3 entities in total)
• Functional Keywords: transferase, inhibitor, map kinase, serine/ threonine-protein kinase, p38, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 44046.09

Authors

Zhao, B.,Clark, M.A. (deposition date: 2009-05-01, release date: 2009-08-04, Last modification date: 2023-09-06)

• Primary citation: Clark, M.A.,Acharya, R.A.,Arico-Muendel, C.C.,Belyanskaya, S.L.,Benjamin, D.R.,Carlson, N.R.,Centrella, P.A.,Chiu, C.H.,Creaser, S.P.,Cuozzo, J.W.,Davie, C.P.,Ding, Y.,Franklin, G.J.,Franzen, K.D.,Gefter, M.L.,Hale, S.P.,Hansen, N.J.,Israel, D.I.,Jiang, J.,Kavarana, M.J.,Kelley, M.S.,Kollmann, C.S.,Li, F.,Lind, K.,Mataruse, S.,Medeiros, P.F.,Messer, J.A.,Myers, P.,O'Keefe, H.,Oliff, M.C.,Rise, C.E.,Satz, A.L.,Skinner, S.R.,Svendsen, J.L.,Tang, L.,van Vloten, K.,Wagner, R.W.,Yao, G.,Zhao, B.,Morgan, B.A.; Design, synthesis and selection of DNA-encoded small-molecule libraries.; Nat.Chem.Biol., 5:647-654, 2009; PubMed: 19648931; DOI: 10.1038/nchembio.211

Experimental method

X-RAY DIFFRACTION (2.48 Å)