3GPQ

Crystal structure of macro domain of Chikungunya virus in complex with RNA

3GPQ の概要

• エントリーDOI: 10.2210/pdb3gpq/pdb
• 関連するPDBエントリー: 3GPG 3GPO 3GQE
• 分子名称: Non-structural protein 3, RNA (5'-R(*AP*AP*A)-3') (3 entities in total)
• 機能のキーワード: macro domain, x domain, chikungunya, alphavirus, virus, vizier. viral enzymes involved in replication, rna, atp-binding, cell membrane, endosome, helicase, hydrolase, lipoprotein, lysosome, membrane, methyltransferase, mrna capping, mrna processing, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, palmitate, phosphoprotein, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, viral protein/rna, viral protein-rna complex
• 由来する生物種: Chikungunya virus
• 細胞内の位置: Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q8JUX6
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 76425.81

構造登録者

Malet, H.,Jamal, S.,Coutard, B.,Canard, B. (登録日: 2009-03-23, 公開日: 2009-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.; The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket; J.Virol., 83:6534-6545, 2009; PubMed: 19386706; DOI: 10.1128/JVI.00189-09

実験手法

X-RAY DIFFRACTION (2 Å)