3GOI

Human glucokinase in complex with a synthetic activator

Summary for 3GOI

Entry DOI	10.2210/pdb3goi/pdb
Descriptor	Glucokinase, alpha-D-glucopyranose, 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ... (4 entities in total)
Functional Keywords	glucokinase, diabetes, allosteric activator, atp-binding, glycolysis, kinase, nucleotide-binding, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	51519.52
Authors	Kamata, K.,Mitsuya, M. (deposition date: 2009-03-19, release date: 2009-04-28, Last modification date: 2024-03-20)
Primary citation	Mitsuya, M.,Kamata, K.,Bamba, M.,Watanabe, H.,Sasaki, Y.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Nagata, Y.,Eiki, J.,Nishimura, T. Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators Bioorg.Med.Chem.Lett., 19:2718-2721, 2009 Cited by PubMed Abstract: A novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class. Subsequent chemical modification led to the discovery of potent GK activators which eliminate potential toxicity concerns associated with an aniline group of the lead structure. Compound 7 demonstrated glucose lowering effect in a rat OGTT model. PubMed: 19362831 DOI: 10.1016/j.bmcl.2009.03.137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation