3GOI
Human glucokinase in complex with a synthetic activator
Summary for 3GOI
Entry DOI | 10.2210/pdb3goi/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ... (4 entities in total) |
Functional Keywords | glucokinase, diabetes, allosteric activator, atp-binding, glycolysis, kinase, nucleotide-binding, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 51519.52 |
Authors | Kamata, K.,Mitsuya, M. (deposition date: 2009-03-19, release date: 2009-04-28, Last modification date: 2024-03-20) |
Primary citation | Mitsuya, M.,Kamata, K.,Bamba, M.,Watanabe, H.,Sasaki, Y.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Nagata, Y.,Eiki, J.,Nishimura, T. Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators Bioorg.Med.Chem.Lett., 19:2718-2721, 2009 Cited by PubMed: 19362831DOI: 10.1016/j.bmcl.2009.03.137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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