3GOI

Human glucokinase in complex with a synthetic activator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0003824	molecular_function	catalytic activity
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006007	biological_process	glucose catabolic process
A	0006096	biological_process	glycolytic process
A	0006110	biological_process	regulation of glycolytic process
A	0006163	biological_process	purine nucleotide metabolic process
A	0006739	biological_process	NADP+ metabolic process
A	0008865	molecular_function	fructokinase activity
A	0009749	biological_process	response to glucose
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0032024	biological_process	positive regulation of insulin secretion
A	0032869	biological_process	cellular response to insulin stimulus
A	0042593	biological_process	glucose homeostasis
A	0043266	biological_process	regulation of potassium ion transport
A	0044320	biological_process	cellular response to leptin stimulus
A	0045721	biological_process	negative regulation of gluconeogenesis
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0046496	biological_process	nicotinamide nucleotide metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0050796	biological_process	regulation of insulin secretion
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	0061621	biological_process	canonical glycolysis
A	0070509	biological_process	calcium ion import
A	0141089	molecular_function	glucose sensor activity

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvrhedIDkgiLlnWTKgF

Chain	Residue	Details
A	LEU146-PHE171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	239
Details	Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15016359","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22101819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ID8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 592

Chain	Residue	Details
A	LYS169	proton acceptor, proton donor
A	ASP205	metal ligand, proton acceptor, proton donor

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