3GKH
NPC1(NTD)
Summary for 3GKH
Entry DOI | 10.2210/pdb3gkh/pdb |
Related | 3GKI 3GKJ |
Descriptor | Niemann-Pick C1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cholesterol, cholesterol transfer, disease mutation, endosome, glycoprotein, lysosome, membrane, transmembrane, transport protein |
Biological source | Homo sapiens (human) |
Cellular location | Late endosome membrane; Multi-pass membrane protein: O15118 |
Total number of polymer chains | 1 |
Total formula weight | 26568.74 |
Authors | Kwon, H.J. (deposition date: 2009-03-10, release date: 2009-07-14, Last modification date: 2021-10-20) |
Primary citation | Kwon, H.J.,Abi-Mosleh, L.,Wang, M.L.,Deisenhofer, J.,Goldstein, J.L.,Brown, M.S.,Infante, R.E. Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell(Cambridge,Mass.), 137:1213-1224, 2009 Cited by PubMed: 19563754DOI: 10.1016/j.cell.2009.03.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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