3GK6

Crystal structure from the mobile metagenome of Vibrio cholerae. Integron cassette protein VCH_CASS2.

Summary for 3GK6

• Entry DOI: 10.2210/pdb3gk6/pdb
• Descriptor: Integron cassette protein VCH_CASS2, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL (3 entities in total)
• Functional Keywords: novel, integron cassette protein, vibrio cholerae, oyster pond, woods hole, usa, structural genomics, psi-2, protein structure initiative, midwest center for structural genomics, mcsg, unknown function
• Biological source: Vibrio cholerae
• Total number of polymer chains: 1
• Total formula weight: 19837.33

Authors

Deshpande, C.N.,Sureshan, V.,Harrop, S.J.,Boucher, Y.,Xu, X.,Cui, H.,Edwards, A.M.,Savchenko, A.,Joachimiak, A.,Chang, C.,Stokes, H.W.,Curmi, P.M.G.,Mabbutt, B.C.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2009-03-10, release date: 2009-03-24, Last modification date: 2024-10-09)

Primary citation

Deshpande, C.N.,Harrop, S.J.,Boucher, Y.,Hassan, K.A.,Leo, R.D.,Xu, X.,Cui, H.,Savchenko, A.,Chang, C.,Labbate, M.,Paulsen, I.T.,Stokes, H.W.,Curmi, P.M.,Mabbutt, B.C.
Crystal Structure of an Integron Gene Cassette-Associated Protein from Vibrio cholerae Identifies a Cationic Drug-Binding Module.
Plos One, 6:e16934-e16934, 2011

PubMed Abstract: The direct isolation of integron gene cassettes from cultivated and environmental microbial sources allows an assessment of the impact of the integron/gene cassette system on the emergence of new phenotypes, such as drug resistance or virulence. A structural approach is being exploited to investigate the modularity and function of novel integron gene cassettes.

PubMed: 21390267
DOI: 10.1371/journal.pone.0016934

Experimental method

X-RAY DIFFRACTION (1.8 Å)