3GI4
Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease
Summary for 3GI4
Entry DOI | 10.2210/pdb3gi4/pdb |
Related | 3GI5 3GI6 |
Descriptor | Protease, 5S)-N-[(1S,2R)-3-[(1,3-Benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxo-3-[3-(tr ifluoromethyl)phenyl]-5-oxazolidinecarboxamide, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | drug design, protease inhibitors, hiv-1 protease, aspartyl protease, hydrolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22617.30 |
Authors | Nalam, M.N.L.,Schiffer, C.A. (deposition date: 2009-03-05, release date: 2010-03-09, Last modification date: 2024-02-21) |
Primary citation | Nalam, M.N.,Ali, A.,Altman, M.D.,Reddy, G.S.,Chellappan, S.,Kairys, V.,Ozen, A.,Cao, H.,Gilson, M.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A. Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J.Virol., 84:5368-5378, 2010 Cited by PubMed: 20237088DOI: 10.1128/JVI.02531-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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