3G0W
Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor
Summary for 3G0W
Entry DOI | 10.2210/pdb3g0w/pdb |
Descriptor | Androgen receptor, 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-met hylbenzonitrile (3 entities in total) |
Functional Keywords | androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, ubl conjugation, zinc, zinc-finger, hormone-growth factor complex, hormone |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Nucleus: P15207 |
Total number of polymer chains | 1 |
Total formula weight | 30642.15 |
Authors | Sack, J.S. (deposition date: 2009-01-29, release date: 2009-04-28, Last modification date: 2024-02-21) |
Primary citation | Nirschl, A.A.,Zou, Y.,Krystek, S.R.,Sutton, J.C.,Simpkins, L.M.,Lupisella, J.A.,Kuhns, J.E.,Seethala, R.,Golla, R.,Sleph, P.G.,Beehler, B.C.,Grover, G.J.,Egan, D.,Fura, A.,Vyas, V.P.,Li, Y.X.,Sack, J.S.,Kish, K.F.,An, Y.,Bryson, J.A.,Gougoutas, J.Z.,DiMarco, J.,Zahler, R.,Ostrowski, J.,Hamann, L.G. N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation. J.Med.Chem., 52:2794-2798, 2009 Cited by PubMed: 19351168DOI: 10.1021/jm801583j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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