3G0W

Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor

Summary for 3G0W

• Entry DOI: 10.2210/pdb3g0w/pdb
• Descriptor: Androgen receptor, 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-met hylbenzonitrile (3 entities in total)
• Functional Keywords: androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, ubl conjugation, zinc, zinc-finger, hormone-growth factor complex, hormone
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Nucleus: P15207
• Total number of polymer chains: 1
• Total formula weight: 30642.15

Authors

Sack, J.S. (deposition date: 2009-01-29, release date: 2009-04-28, Last modification date: 2024-02-21)

Primary citation

Nirschl, A.A.,Zou, Y.,Krystek, S.R.,Sutton, J.C.,Simpkins, L.M.,Lupisella, J.A.,Kuhns, J.E.,Seethala, R.,Golla, R.,Sleph, P.G.,Beehler, B.C.,Grover, G.J.,Egan, D.,Fura, A.,Vyas, V.P.,Li, Y.X.,Sack, J.S.,Kish, K.F.,An, Y.,Bryson, J.A.,Gougoutas, J.Z.,DiMarco, J.,Zahler, R.,Ostrowski, J.,Hamann, L.G.
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
J.Med.Chem., 52:2794-2798, 2009

PubMed Abstract: A novel selective androgen receptor modulator (SARM) scaffold was discovered as a byproduct obtained during synthesis of our earlier series of imidazolidin-2-ones. The resulting oxazolidin-2-imines are among the most potent SARMs known, with many analogues exhibiting sub-nM in vitro potency in binding and functional assays. Despite the potential for hydrolytic instability at gut pH, compounds of the present class showed good oral bioavailability and were highly active in a standard rodent pharmacological model.

PubMed: 19351168
DOI: 10.1021/jm801583j

Experimental method

X-RAY DIFFRACTION (1.95 Å)