3FZD

Mutation of Asn28 disrupts the enzymatic activity and dimerization of SARS 3CLpro

Summary for 3FZD

Entry DOI	10.2210/pdb3fzd/pdb
Related	2C3S 2bx4 3D62
Descriptor	3C-like proteinase (2 entities in total)
Functional Keywords	sars, sars 3clpro, protease, sars-cov mpro, dimerization, analytical ultracentrifugation, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger
Biological source	SARS coronavirus (virus)
Total number of polymer chains	1
Total formula weight	33301.03
Authors	Barrila, J.,Gabelli, S.,Bacha, U.,Amzel, L.M.,Freire, E. (deposition date: 2009-01-25, release date: 2010-05-05, Last modification date: 2023-09-06)
Primary citation	Barrila, J.,Gabelli, S.B.,Bacha, U.,Amzel, L.M.,Freire, E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry, 49:4308-4317, 2010 Cited by PubMed: 20420403 DOI: 10.1021/bi1002585 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation