3FX6
X-RAY crystallographic studies on the complex of carboxypeptidase A with the inhibitor using alpha-nitro ketone as the zinc-binding group
Summary for 3FX6
Entry DOI | 10.2210/pdb3fx6/pdb |
Descriptor | Carboxypeptidase A1, ZINC ION, (2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid, ... (4 entities in total) |
Functional Keywords | alpha-nitro ketone, inhibitor, hydrolase, carboxypeptidase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen |
Biological source | Bos taurus (Bovine) |
Cellular location | Secreted, extracellular space: P00730 |
Total number of polymer chains | 3 |
Total formula weight | 104514.34 |
Authors | Wang, S.F.,Jin, J.Y.,Tian, G.R. (deposition date: 2009-01-20, release date: 2009-08-25, Last modification date: 2024-10-16) |
Primary citation | Wang, S.F.,Tian, G.R.,Zhang, W.Z.,Jin, J.Y. Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A Bioorg.Med.Chem.Lett., 19:5009-5011, 2009 Cited by PubMed: 19646864DOI: 10.1016/j.bmcl.2009.07.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.851 Å) |
Structure validation
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