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3FUG

Crystal Structure of the Retinoid X Receptor Ligand Binding Domain Bound to the Synthetic Agonist 3-[4-Hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]acrylic Acid

Summary for 3FUG
Entry DOI10.2210/pdb3fug/pdb
Related2p1t 2p1u 2p1v
DescriptorRetinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E)-3-[4-hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]prop-2-enoic acid, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, hormone receptor, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, activator, phosphoprotein, transcription-transcription regulator complex, transcription/transcription regulator
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P19793 Q15596
Total number of polymer chains2
Total formula weight28756.37
Authors
Bourguet, W. (deposition date: 2009-01-14, release date: 2009-05-12, Last modification date: 2023-09-06)
Primary citationPerez Santin, E.,Germain, P.,Quillard, F.,Khanwalkar, H.,Rodriguez-Barrios, F.,Gronemeyer, H.,de Lera, A.R.,Bourguet, W.
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
J.Med.Chem., 52:3150-3158, 2009
Cited by
PubMed: 19408900
DOI: 10.1021/jm900096q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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