3FS6

Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Summary for 3FS6

Entry DOI	10.2210/pdb3fs6/pdb
Related	1u72
Descriptor	Dihydrofolate reductase, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	human wild type dhfr active site inhibitors, nadp, one-carbon metabolism, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22572.53
Authors	Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. (deposition date: 2009-01-09, release date: 2009-08-18, Last modification date: 2023-09-06)
Primary citation	Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes. Biochemistry, 48:1702-1711, 2009 Cited by PubMed: 19196009 DOI: 10.1021/bi801960h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.23 Å)

Structure validation