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3FQW

Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes

Summary for 3FQW
Entry DOI10.2210/pdb3fqw/pdb
Related3FQN 3FQR 3FQT 3FQU 3FQX
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, peptide 1097-1105 from insulin receptor substrate 2 (IRS2): RVASPTSGV, ... (6 entities in total)
Functional Keywordsimmune system, phosphorylation, glycoprotein, immune response, membrane, mhc i, phosphoprotein, polymorphism, transmembrane, ubl conjugation, disease mutation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, cancer, tcr, self-epitope
Biological sourceHomo sapiens (Human)
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Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains3
Total formula weight44984.17
Authors
Petersen, J.,Rossjohn, J. (deposition date: 2009-01-07, release date: 2009-03-03, Last modification date: 2023-11-01)
Primary citationPetersen, J.,Wurzbacher, S.J.,Williamson, N.A.,Ramarathinam, S.H.,Reid, H.H.,Nair, A.K.,Zhao, A.Y.,Nastovska, R.,Rudge, G.,Rossjohn, J.,Purcell, A.W.
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
Proc.Natl.Acad.Sci.Usa, 106:2776-2781, 2009
Cited by
PubMed: 19196958
DOI: 10.1073/pnas.0812901106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.927 Å)
Structure validation

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