3FFD
Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody
Summary for 3FFD
Entry DOI | 10.2210/pdb3ffd/pdb |
Descriptor | Monoclonal antibody, heavy chain, Fab fragment, Monoclonal antibody, light chain, Fab fragment, Parathyroid hormone-related protein, ... (4 entities in total) |
Functional Keywords | pthrp complexed to fab, cleavage on pair of basic residues, hormone, nucleus, secreted, immune system-hormone complex, immune system/hormone |
Biological source | Mus musculus (mouse) More |
Cellular location | Cytoplasm: P12272 |
Total number of polymer chains | 3 |
Total formula weight | 59688.98 |
Authors | Mckinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W. (deposition date: 2008-12-03, release date: 2009-04-28, Last modification date: 2023-11-01) |
Primary citation | McKinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W. Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor J.Biol.Chem., 284:15557-15563, 2009 Cited by PubMed: 19346515DOI: 10.1074/jbc.M900044200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report