3FFD

Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody

Summary for 3FFD

• Entry DOI: 10.2210/pdb3ffd/pdb
• Descriptor: Monoclonal antibody, heavy chain, Fab fragment, Monoclonal antibody, light chain, Fab fragment, Parathyroid hormone-related protein, ... (4 entities in total)
• Functional Keywords: pthrp complexed to fab, cleavage on pair of basic residues, hormone, nucleus, secreted, immune system-hormone complex, immune system/hormone
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm: P12272
• Total number of polymer chains: 3
• Total formula weight: 59688.98

Authors

Mckinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W. (deposition date: 2008-12-03, release date: 2009-04-28, Last modification date: 2023-11-01)

• Primary citation: McKinstry, W.J.,Polekhina, G.,Diefenbach-Jagger, H.,Ho, P.W.M.,Sato, K.,Onuma, E.,Gillespie, M.T.,Martin, T.J.,Parker, M.W.; Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor; J.Biol.Chem., 284:15557-15563, 2009; PubMed: 19346515; DOI: 10.1074/jbc.M900044200

Experimental method

X-RAY DIFFRACTION (2 Å)