3FCB
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH
Summary for 3FCB
Entry DOI | 10.2210/pdb3fcb/pdb |
Related | 3FC8 |
Descriptor | transthyretin, N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINE (3 entities in total) |
Functional Keywords | transthyretin, amyloid, inhibitors, iodine, polymorphism, polyneuropathy, retinol-binding, secreted, hormone binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 27738.25 |
Authors | Gales, L.,Damas, A.M. (deposition date: 2008-11-21, release date: 2009-02-17, Last modification date: 2023-09-06) |
Primary citation | Mairal, T.,Nieto, J.,Pinto, M.,Almeida, M.R.,Gales, L.,Ballesteros, A.,Barluenga, J.,Perez, J.J.,Vazquez, J.T.,Centeno, N.B.,Saraiva, M.J.,Damas, A.M.,Planas, A.,Arsequell, G.,Valencia, G. Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. Plos One, 4:e4124-e4124, 2009 Cited by PubMed: 19125186DOI: 10.1371/journal.pone.0004124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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