3FC1
Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor
Summary for 3FC1
Entry DOI | 10.2210/pdb3fc1/pdb |
Descriptor | Mitogen-activated protein kinase 14, CHLORIDE ION, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, ... (4 entities in total) |
Functional Keywords | kinase inhibitor, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42470.65 |
Authors | Jacobs, M.D.,Bellon, S. (deposition date: 2008-11-20, release date: 2008-12-09, Last modification date: 2023-12-27) |
Primary citation | Pearlman, D.A. Evaluating the molecular mechanics poisson-boltzmann surface area free energy method using a congeneric series of ligands to p38 MAP kinase. J.Med.Chem., 48:7796-7807, 2005 Cited by PubMed: 16302819DOI: 10.1021/jm050306m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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