3FC1
Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Mitogen-activated protein kinase 14 | polymer | 366 | 41998.9 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (X) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (X) | 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one | non-polymer | 436.3 | 1 | Chemie (52P) | |||
| 4 | D (X) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
X: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41998.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 471.7 | |
| All* | Total formula weight | 42470.7 |
