3F6X

c-Src kinase domain in complex with small molecule inhibitor

Summary for 3F6X

Entry DOI	10.2210/pdb3f6x/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile (3 entities in total)
Functional Keywords	kinase, atp-binding, alternative splicing, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
Biological source	Gallus gallus (bantam,chickens)
Cellular location	Cell membrane (By similarity): P00523
Total number of polymer chains	4
Total formula weight	132432.31
Authors	Seeliger, M.A.,Statsuk, A.V.,Maly, D.J.,Patrick, P.Z.,Kuriyan, J.,Shokat, K.M. (deposition date: 2008-11-06, release date: 2008-12-09, Last modification date: 2023-09-06)
Primary citation	Statsuk, A.V.,Maly, D.J.,Seeliger, M.A.,Fabian, M.A.,Biggs, W.H.,Lockhart, D.J.,Zarrinkar, P.P.,Kuriyan, J.,Shokat, K.M. Tuning a three-component reaction for trapping kinase substrate complexes. J.Am.Chem.Soc., 130:17568-17574, 2008 Cited by PubMed: 19053485 DOI: 10.1021/ja807066f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation