3F6X
c-Src kinase domain in complex with small molecule inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 4 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (bantam chickens) | pp60c-src, p60-Src, c-Src |
2 | A, B, C, D | [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | non-polymer | 381.4 | 4 | Chemie (IHH) | |||
3 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 251 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 130906.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1525.7 | |
All* | Total formula weight | 132432.3 |